Advancing Dermatological Research: Humanized Rodent Models and Innovative Approaches in Skin Disease Modeling

EasyChair Preprint no. 12458

Abstract

This research paper delves into the development and characterization of humanized mouse and rat models featuring full-thickness human skin grafts, aiming to closely mimic human physiology for dermatological research, drug development, and transplantation studies. The study outlines a meticulous methodology for generating these models, assesses their viability, and explores implications for advancing our understanding of skin biology and pathology. The successful integration of full-thickness human skin into rodent hosts is highlighted, offering promising avenues for translational research in dermatology. The second part of the paper focuses on an extensive review of immune-competent human skin disease models, emphasizing their crucial role in drug discovery. The review addresses limitations in current models, explores innovative in vitro alternatives, scrutinizes diseases like fibrosis, autoimmune disorders, psoriasis, cancer, and contact allergy, and underscores the need for superior non-animal, human immune-competent, and scalable skin disease models with comprehensive biomarkers. The urgent call for accurate drug discovery methodologies aligning with ethical guidelines, including the 3Rs, is emphasized throughout.

Keyphrases: Dermatological Research, Humanized rodent models, Skin Disease Modeling

@Booklet{EasyChair:12458,
  author = {Liis Tammik},
  title = {Advancing Dermatological Research: Humanized Rodent Models and Innovative Approaches in Skin Disease Modeling},
  howpublished = {EasyChair Preprint no. 12458},

  year = {EasyChair, 2024}}