Transforming Disease Modeling and Charting the Course to Personalized Medicine Through Humanized Mice

EasyChair Preprint no. 12433

Abstract

This paper delves into the revolutionary realm of humanized mice, marking a significant departure in preclinical animal models through the integration of functional human cells and tissues into immunodeficient mouse hosts. The evolution of humanized mice, initiated by the introduction of immunodeficient mice with IL2 receptor common gamma chain mutations (IL2rgnull) in the early 2000s, is explored comprehensively. The discussion emphasizes the pivotal role played by these mice in advancing our comprehension of infectious diseases, cancer, regenerative medicine, graft-versus-host disease, allergies, and immunity. From their nascent stage, humanized mice have matured into versatile platforms for disease modeling, making substantial contributions to both fundamental and translational research.

Keyphrases: Humanized Mice, personalized medicine, Transforming Disease

@Booklet{EasyChair:12433,
  author = {Liis Tammik},
  title = {Transforming Disease Modeling and Charting the Course to Personalized Medicine Through Humanized Mice},
  howpublished = {EasyChair Preprint no. 12433},

  year = {EasyChair, 2024}}