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![]() Title:ICU-TSB: A Benchmark for Temporal Patient Representation Learning for Unsupervised Stratification into Patient Cohorts Authors:Dimitrios Proios, Alban Bornet, Anthony Yazdani, Jose Fernando Rodrigues Jr and Douglas Teodoro Conference:IEEE CBMS 2025 Tags:Electronic Health Records, Hierarchical clustering, ICU data, Patient representation learning, Patient stratification, Temporal embeddings and Unsupervised stratification Abstract: Patient stratification—identifying clinically meaningful subgroups—enhances personalized medicine by improving diagnostics and treatment strategies. Electronic Health Records (EHRs) capture rich temporal clinical data recorded throughout hospital care. We leverage four public Intensive Care Unit (ICU) EHR datasets to introduce the first benchmark for evaluating patient stratification over temporal patient repre- sentation learning. We compare statistical methods, LSTMs, and GRUs for generating patient representations and assess their effectiveness in clustering patient trajectories. Using ICD and CCS taxonomies, we propose a hierarchical stratifi- cation benchmark to measure alignment with clinically validated disease groupings. Our results demonstrate that temporal representation learning effectively rediscovers clinically meaningful patient cohorts, achieving state-of-the-art clustering. To further enhance interpretability, we evaluate multiple cluster label assignment strategies. The experiments and benchmark are fully reproducible and available at https://github.com/ds4dh/CBMS2025stratification. ICU-TSB: A Benchmark for Temporal Patient Representation Learning for Unsupervised Stratification into Patient Cohorts ![]() ICU-TSB: A Benchmark for Temporal Patient Representation Learning for Unsupervised Stratification into Patient Cohorts | ||||
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