The number of total and partial knee arthroplasties performed annually in the United Kingdom increased steadily between 2003-2019. Early intervention through targeted treatment of focal cartilage lesions could avoid or postpone the need for more complex and invasive procedures, but such interventions are still uncommon. Among the key challenges of these procedures is the difficulty of ensuring correct positioning and a good congruence between the implant and patient anatomy, which are critical for success. In this regard, Computer-Assisted Orthopaedic Surgery (CAOS) could be of assistance, as it provides valuable metrics to inform the selection and placement of an implant, and minimise the error between planning and execution. CAOS systems promise to bring more quantitative data and objective metrics into the operating theatre, informing the surgeons’ decisions, thus allowing them to tailor each intervention to the patient’s needs. This work presents the validation of a novel computer-assisted surgical workflow for the treatment of osteochondral lesions. The software uses intraoperative information on the patient’s anatomy and lesion to help clinicians optimise the selection of an implant and its pose. The software was combined with the existing capabilities of the NAVIO™ surgical system (Smith & Nephew inc.), creating a complete workflow that incorporates both surgical planning and assisted bone preparation.