We introduce a universe of regular datatypes with variable binding information, for which we define generic formation, elimination, and induction operators. We then define a generic $\alpha$-equivalence relation over the types of the universe based on name-swapping, and derive iteration and induction principles which work modulo $\alpha$-conversion capturing Barendregt's Variable Convention. We instantiate the resulting framework so as to obtain the $\lambda$-Calculus and System F, for which we derive substitution operations and substitution lemmas for $\alpha$-conversion and substitution composition. The whole work is carried out in Constructive Type Theory and machine-checked by the system Agda.