Accurately detecting pain in infants remains a complex challenge. Conventional deep neural networks used for analyzing infant cry sounds typically demand large labeled datasets, substantial computational power, and often lack interpretability. In this work, we introduce a novel approach that leverages OpenAI’s vision-language model, GPT-4(V), combined with mel spectrogram-based representations of infant cries through prompting. This prompting strategy significantly reduces the dependence on large training datasets while enhancing transparency and interpretability. Using the USF-MNPAD-II dataset, our method achieves an accuracy of 83.33% with only 16 training samples, in contrast to the 4,914 samples required in the baseline model. To our knowledge, this represents the first application of few-shot prompting with vision-language models such as GPT-4o for infant pain classification.