This study presents the development and evaluation of a gamified simulation platform designed to enhance laboratory-based learning in higher education. Integrating artificial intelligence (AI), virtual and augmented reality (VR/AR), and smart system components, the platform was piloted across disciplines including biochemistry, materials science, and computer engineering. A mixed-methods approach—combining surveys, platform prototyping, and usability testing—demonstrated that gamified simulations significantly improve student engagement, conceptual understanding, and task completion rates compared to traditional lab formats. Key features include immersive visualizations, adaptive feedback loops, and interactive scenarios aligned with course-specific objectives. Survey data from 187 students revealed strong support for competitive and narrative-based lab tasks. At the same time, pilot results confirmed increased motivation and effective learning under both normal and disrupted conditions, such as remote learning during crises. The platform encourages creativity, experimentation, and autonomy by enabling safe digital environments for hands-on exploration. This work underscores the potential of AI-enhanced, gamified simulation tools to support scalable, resilient, and student-centered education. It offers a model for integrating cutting-edge technologies into university curricula.