The paper carries out the strategic analysis of innovative possibilities of Zaporizhzhia region’s industrial complex and investigates the indicators of innovative activity of industrial complexes of Zaporizhzhia region and Ukraine by Harrington’s generalized desirability function. The evaluation results prove the “good” ability and readiness of the industrial complex of Zaporizhzhia region and Ukraine to carry out effective innovation activities. However, according to the comparative assessment of the innovative activity of Zaporizhzhia region’s industrial complex and Ukraine’s one, Zaporizhzhia region’s industrial complex is found to lag 9.2% behind Ukraine’s. A cluster development strategy is suggested to improve the innovative development management of Zaporizhzhia region’s industrial complex