The Rotating Detonation Combustor (RDC) is an emerging technology in the field of propulsion that shows great promise in terms of potential for significant improvements in fuel efficiency and power density when compared to conventional combustion systems. The combustion process in RDCs involves both deflagration and detonation, as well as complex fluid dynamics, including oblique and reflected shock waves. Because of this complexity, the chemical mechanisms are crucial for developing accurate numerical models of RDCs. In this study, a two-dimensional RDC simulation was conducted utilizing three distinct chemical mechanisms. The objective of the study was to elucidate the disparities between the chemistry models. For this study, the following chemical mechanisms were selected for comparison: Burke, USCD, and one-step chemistry mechanisms. For comparison, a range of metrics was analyzed, including, but not limited to, parameters such as detonation height and peak values of static pressure and temperature. In addition, the mass fraction of some important species was analyzed to provide a comprehensive overview. The one-step chemistry mechanism serves as the baseline in this study. The results indicate that using the Burke chemical mechanism results in a lower detonation height, while higher values for pressure and temperature are observed. In simulations using the USCD chemical mechanism, the results are comparable to the baseline case, although they do not completely align. Additionally, OH chemiluminescence imaging has been identified as an effective method for recognizing the detonation wave in experimental studies. A significant limitation of the one-step chemistry mechanism is the absence of the OH radical, which is present in both the Burke and USCD mechanisms. Furthermore, numerical Schlieren images were obtained for each chemical mechanism and compared to enable a more detailed analysis of the wavefront.